Lung pathology in septic shock.

Lung Changes in Shock

In the very beginning stage of the lung changes are Perivascular, capillary wall edema, thickening of the interstitial, lymph and vascular dilatation.  In the late stage of the shock the following changes will occuree  Microthromboses of the lung capillary, polynulcear in­filtration into the interstitial, the existence of polynu­clear in the alveoli, proliferation of interstitial mesenchy­ma,...

Septic Shock

Pediatric severe sepsis and septic shock continue to be significant causes of childhood morbidity and mortality worldwide. The following review will highlight some of the controversies surrounding the consensus definitions. It will chronicle recent clinical and translational research, focusing on pediatric sepsis-specific challenges investigators face. It will also address the pathophysiology o...

Septic shock.

Septic shock, the most severe complication of sepsis, is a deadly disease. In recent years, exciting advances have been made in the understanding of its pathophysiology and treatment. Pathogens, via their microbial-associated molecular patterns, trigger sequential intracellular events in immune cells, epithelium, endothelium, and the neuroendocrine system. Proinflammatory mediators that contrib...

Septic Shock in Neonates

Vasopressin in septic shock

Vasopressin (also known as antidiuretic hormone) is a nonapeptide produced in the paraventricular and supraoptic nuclei of the hypothalamaus and released from the posterior pituitary. It has two distinct roles that underlie its two names. In health, its main effect is to act in the control of osmolarity. Stimulation of vasopressin receptors (V2) in the distal convoluted tubule of the kidney res...